Sermorelin — Synthetic Growth Hormone-Releasing Peptide For Research
Sermorelin (Growth Hormone-Releasing Hormone 1-29 amide) is a synthetic peptide analog designed for growth hormone axis and endocrine pathway research. Derived from the first 29 amino acids of endogenous GHRH, Sermorelin is engineered to retain full biological activity while selectively interacting with growth hormone-releasing hormone receptors (GHRH-R) in pituitary tissue. Its receptor specificity makes it a valuable compound for studying growth hormone secretion dynamics and downstream signaling pathways.
Mechanism Of Action
Sermorelin stimulates growth hormone release by binding to GHRH receptors located on pituitary somatotroph cells. This interaction activates adenylate cyclase and cyclic AMP (cAMP) pathways, leading to increased intracellular signaling and pulsatile growth hormone secretion. Research indicates that Sermorelin may influence insulin-like growth factor-1 (IGF-1) expression, protein synthesis pathways, and tissue growth signaling while maintaining normal physiological feedback mechanisms.
Research Applications
- Growth hormone secretion and endocrine signaling studies
- Pituitary receptor activation research
- IGF-1 expression and downstream pathway analysis
- Cellular growth and protein synthesis investigations
- Comparative studies with growth hormone secretagogues and peptides
- Neuroendocrine axis and metabolic signaling research
Product Specifications
- Quantity: 10mg per vial
- Product Weight: 1oz
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: Refrigerate once reconstituted
- Testing: USA lab tested, COA available
Not for human use or consumption. For research use only.
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